Optimization of bioreducible micelles self-assembled from amphiphilic hyperbranched block copolymers for drug delivery
نویسندگان
چکیده
منابع مشابه
Unimolecular micelles of amphiphilic cyclodextrin-core star-like block copolymers for anticancer drug delivery.
Well-defined star-like amphiphilic polymers composed of a β-cyclodextrin core, from which 21 hydrophobic poly(lactic acid) arms and hydrophilic poly(ethylene glycol) arms are grafted sequentially, form robust and uniform unimolecular micelles that are biocompatible and efficient in the delivery of anticancer drugs.
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Amphiphilic block copolymer micelles have been the focus of research for the last decades because of the promising properties as nano size drug delivery vehicles. In polar aqueous milieu, copolymers self assemble into micelle structures which consist of hydrophilic corona and hydrophobic core regions. Space created inside the micelle core can be used for transportation of drug molecules of hydr...
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We report here a discovery that amphiphilic polypeptide block copolymers and polypeptide homopolymers are able to aggregate together into super-helical structures of rods and rings, in which polypeptide chains form the core and PEG chains form the shell.
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Brush-shaped amphiphilic block copolymers were conjugated with a monoclonal antibody against CD105 (i.e., TRC105) and a macrocyclic chelator for (64)Cu-labeling to generate multifunctional theranostic unimolecular micelles. The backbone of the brush-shaped amphiphilic block copolymer was poly(2-hydroxyethyl methacrylate) (PHEMA) and the side chains were poly(L-lactide)-poly(ethylene glycol) (PL...
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Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or ...
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ژورنال
عنوان ژورنال: Journal of Polymer Science Part A: Polymer Chemistry
سال: 2018
ISSN: 0887-624X
DOI: 10.1002/pola.29019